Heart failure is a continuous, progressive disease—are your patients’ therapies optimized?
Even if your heart failure patients seem clinically stable, their underlying disease may be progressing1-3
Adapted from Mesquita ET, Jorge AJL, Rabelo LM, et al. Int J Cardiovasc Sci. 2017;30(1):81-90. ©The International Journal of Cardiovascular Sciences
Sudden cardiac death accounts for 40% to 45% of all deaths in HFrEF patients4
In a study with a median follow-up of 27 months, 1 hospitalization put HFrEF patients at up to 6x greater risk of death vs those who had not been hospitalized for HFrEF5,6†
†Post hoc analysis of the PARADIGM-HF study, a multinational, randomized, double-blind trial comparing sacubitril/valsartan to enalapril in 8442 symptomatic (NYHA Class II–IV) HFrEF patients (LVEF ≤40%). For the primary end point, composite of CV death or first HF hospitalization, sacubitril/valsartan was superior to enalapril (P<.0001). This post hoc analysis examined the association of first nonfatal events—either HF hospitalization, ED visit, or outpatient intensification of HF therapy—with subsequent mortality during the trial. For the 1107 patients in the study who had a hospitalization for worsening HF as a first event, vs those with no event, the HR for mortality was 6.1 (95% CI: 5.4–6.8).5,6
*In PARAGON-HF, defined as LVEF ≥45% with structural heart disease (LAE or LVH); median LVEF was 57%. LVEF is a variable measure and the normal range can vary.6